Calcineurin A Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-Calcineurin A Polyclonal Antibody detects endogenous levels of calcineurin A protein. Sequence homology predicts that it will also react with rat calcineurin A.

Calcineurin is a heterodimer protein that binds to Ca2+. A Ca2+/calmodulin-regulated protein phosphatase, it is composed of a 19 kD calcineurin B (CnB) and a 61 kD calmodulin-binding catalytic subunit, calcineurin A (CnA). Calcineurin A was first detected in skeletal muscle and brain tissues, but it has since been found in all cell types, from yeast to mammalian. Calcineurin A may be responsible for the calmodulin activation property of calcineurin. There is evidence suggesting that alternative splicing could give rise to different forms of calcineurin A. GenScript, Rabbit Anti-Calcineurin A Polyclonal Antibody, is developed in rabbit hosts using a KLH-coupled synthetic peptide within residues 450-500 of human calcineurin A protein (Swiss Prot: Q08209).

Immunoaffinity chromatography

115 kD, 60 kD, 32 kD

Small volumes of antibody will occasionally become trapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.