beta-Catenin Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-β, -Catenin Polyclonal Antibody detects human β, -catenin protein. Predicted to react with rat according to sequence homology.

beta-Catenin is an adherens junction protein. Adherens junctions (also called AJs and the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate signals that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. GenScript, Rabbit Anti-beta-Catenin Polyclonal Antibody, is developed in rabbit hosts using a synthetic peptide (KLH-coupled) within residues 30-80 of human beta-catenin protein (Swiss Prot: P35222).

Immunoaffinity chromatography

90 kD