Creatine kinase MB Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-Creatine kinase MB Polyclonal Antibody detects endogenous levels of human, mouse and rat Creatine kinase M and Creatine kinase B. Positive Control: HEK293, SH-SY5Y, mouse brain and rat brain.

Creatine kinase (CK) is a major enzyme involved in energy metabolism in tissues with large fluctuations of energetic demand. CK catalyses the reversible transfer of a high energy phosphoryl group between ATP and phosphocreatine. Creatine kinase consists of B subunit (brain type) and M subunit (muscle type) and therefore three different cytosolic isoenzymes exist: CK-MM, CK-BB and CK-MB. The major muscle isoform, CK-MM, is a homodimer of the M subunit. In contrast to muscle, the major creatine kinase isoform in brain is BB creatine kinase. In a few tissues, especially myocardium, a heterodimeric isoform MB creatine kinase is present. GenScript, Rabbit Anti-Creatine kinase MB Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide within residues 300ca.350 of human Creatine kinase M (Swiss Prot: P06732) and Creatine kinase B (Swiss Prot: P12277).

Immunoaffinity chromatography