MeCP2 antibody, pAb, Rabbit

USA

GenScript, MeCP2 Antibody, pAb, Rabbit, detects endogenous levels of human MeCP2. It is predicted to react with rat and mouse MeCP2 according to sequence homology. Positive Control: MCF-7

Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. CDKL5 kinase interacts with MeCP2 and mediates its phosphorylation, which suggests that they belong to the same molecular pathway. MeCP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder. GenScript, MeCP2 Antibody, pAb, Rabbit, is developed in rabbit using a KLH-coupled synthetic peptide within residues 310–360 of human MeCP2 (Swiss Prot: P51608).

Immunoaffinity chromatography

33 KD