Torsin A Antibody, pAb, Rabbit

USA

GenScript, Torsin A Antibody, pAb, Rabbit, detects endogenous levels of human, mouse and rat Torsin A protein. Positive Control: U251, Mouse brain and Rat brain

Torsin A is a member a superfamily of ATPases based on homology and configurational alignment. It is predominantly localized in the contiguous lumen of the nucleaenvelope (NE) and endoplasmic reticulum (ER). It plays an important role in maintaining the integrity of the nuclear envelope. Torsin A is associated with lamin-associated polypeptide 1 (TOR1AIP1) in the inner nuclear membrane (INM) of the NE and with LULL1 (TOR1AIP2) in the ER/NE, as well as with conventional kinesin light chain 1 (KLC1), vimentin and actin in the cytoplasm. It interacts with a novel class of transmembrane proteins that are localized in different subdomains of the ER system, either or both of which may play a role in the pathogenesis of DYT1 dystonia. GenScript, Torsin A Antibody, pAb, Rabbit, is developed in rabbit using a KLH-coupled synthetic peptide within residues 40-90 of human Torsin A (Swiss Prot: O14656).

Immunoaffinity chromatography

42 KD, 48 KD