Orexin B, canine

ArtNr	RP10414-0.5
Hersteller	GenScript
Menge	0.5 mg
Kategorie	Neuroscience Metabolism Glucose Homeostasis Regulation of Appetite Neural Signaling Peptides & Proteins Obesity Peptides
Typ	Peptides
Specific against	other
Purity	> 95%
Sequence	RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2 ; {ARG}{PRO}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP10414-Orexin_B_HCRT_peptide_canine, The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2, orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Store at -20C </td></tr>
Similar products	Orexin
Lieferbar
Country of Origin	USA
Storage Conditions	Store at -20C
Description	The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2, orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release.
C-Terminal	NH2

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Menge: 0.5 mg

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