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Orexin B, canine

Orexin B, canine

Item no.	RP10414-0.5
Manufacturer	GenScript
Amount	0.5 mg
Category	Neuroscience Metabolism Glucose Homeostasis Regulation of Appetite Neural Signaling Peptides & Proteins Obesity Peptides
Type	Peptides
Specific against	other
Purity	> 95%
Sequence	RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2 ; {ARG}{PRO}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP10414-Orexin_B_HCRT_peptide_canine, The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2, orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Store at -20C </td></tr>
Similar products	Orexin
Available
Country of Origin	USA
Storage Conditions	Store at -20C
Description	The hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2, orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release.
C-Terminal	NH2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

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Delivery expected until 9/11/2025

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