IRL-1620

ArtNr	RP13497
Hersteller	GenScript
Menge	0.2 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders By Cell Type Melanoma Peptides & Proteins Peptides By Organ Breast Cancer
Typ	Peptides
Specific against	other
Purity	> 95%
Sequence	Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW ; Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP13497-IRL-1620, IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo. </td></tr><tr><th>Solubility</th><td colspan="7"> Insoluble in water. Dissolve the content with > pH 8.5 buffer. </td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Store at -20C. </td></tr><tr><th>Notes</th><td colspan="7"> This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 uM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 uM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.</td></tr>
Similar products	IRL-1620
Lieferbar
Country of Origin	USA
Storage Conditions	Store at -20C.
Description	IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.
Solubility	Insoluble in water. Dissolve the content with > pH 8.5 buffer.
Notes	This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 uM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 uM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.

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