« Back
Home /
IRL-1620

IRL-1620

Item no.	RP13497
Manufacturer	GenScript
Amount	0.2 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders By Cell Type Melanoma Peptides & Proteins Peptides By Organ Breast Cancer
Type	Peptides
Specific against	other
Purity	> 95%
Sequence	Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW ; Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	peptide/RP13497-IRL-1620, IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo. </td></tr><tr><th>Solubility</th><td colspan="7"> Insoluble in water. Dissolve the content with > pH 8.5 buffer. </td></tr><tr><th>Purity</th><td colspan="7"> > 95% </td></tr><tr><th>Storage</th><td colspan="7"> Store at -20C. </td></tr><tr><th>Notes</th><td colspan="7"> This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 uM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 uM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.</td></tr>
Similar products	IRL-1620
Available
Country of Origin	USA
Storage Conditions	Store at -20C.
Description	IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.
Solubility	Insoluble in water. Dissolve the content with > pH 8.5 buffer.
Notes	This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 uM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 uM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.