IL-16, Human

IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. GenScript, Interleukin (IL)-16, human, produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13, 400 Da.

rHuIL-16 was lyophilized from 1 mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT.

Cytokine, Chemokines & Growth Factors

Lyophilized rHuIL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution rHuIL-16 should be stored at 4C between 2-7 days and for future use below -18C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Cytokines