Platelet-Derived Growth Factor-BB, Human

Lyophilized, recombinant human Platelet-Derived Growth Factor-BB (rhPDGF-BB), remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rhPDGF-BB should be stable up to 4 weeks at 4C or up to 6 months at -20C.

Cytokine, Chemokines & Growth Factors

Platelet Derived Growth Factor (PDGF), is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle, connective tissue, bone and cartilage cells, and some blood cells. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. PDGF which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Recombinant human Platelet-Derived Growth Factor-BB (rhPDGF-BB), produced in Pichia pastoris is a glycosylated polypeptide. rhPDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids) and is obtained by proprietary chromatographic techniques at GenScript.

Lyophilized after extensive dialysis against 10mM acetic acid.