Hersteller |
GenScript
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Menge |
10 ug |
ArtNr |
Z02689-10 |
Targets |
VEGFA, FOXD3, SOD1, FLT1, KDR |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Specificity |
ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg. |
Description |
Vascular Endothelial Growth Factor (VEGF), is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors, fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.Recombinant, human Vascular Endothelial Growth Factor A165 (rhVEGF-A165), produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rhVEGF-A165 has a molecular mass of 38.2kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript. |
Endotoxin Level |
<0.5 EU/ug, determined by LAL method. |
Formulation |
Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0. |
M.W. |
38.2kDa, observed by non-reducing SDS-PAGE |
Note |
, Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, in vitro or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
Product Line |
Cytokine, Chemokines & Growth Factors |
Reconstitution |
Reconstituted in ddH2O at 100 ug/ml. |
Storage |
Lyophilized recombinant, human Vascular Endothelial Growth Factor A165 (rhVEGF-A165), remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rhVEGF-A165 should be stable up to 4 week at 4C or up to 6 months at -20C. |
Manufacturers Category |
Proteins |
Manufacturers Product Line |
Growth Factors |
Product Origin |
USA |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.