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Interleukin-33 (IL-33), Human Europäischer Partner

Hersteller GenScript
Kategorie
Typ Proteins
Specific against Human
Format Sterile Filtered White lyophilized (freeze-dried) powder.
Menge 10ug
ArtNr Z02718-10
Targets CD121a, STAB2, NFKB1, IL33, IL13, IL5, IL4
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Specificity
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤, 0.05ng/ml, corresponding to a specific activity of ≥, 2.0x107units/mg.
Description
IL33, also known as NFHEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription. IL33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL1ª or IL1ß stimulation. IL-33 shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities.
Endotoxin Level
Less than 0.2EU/ug of rHuIL-33 as determined by LAL method.
Formulation
Lyophilized from a 0.2µ, m filtered concentrated solution in PBS, pH7.4.
M.W.
Approximately 17.9 kDa, a single non-glycosylated polypeptide chain containing 160 amino acids.
Product Line
Cytokine, Chemokines & Growth Factors
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
Storage
This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
Usage
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Product Origin
USA

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10ug
Lieferbar: In stock
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Lieferung vsl. bis 18.04.2024 

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