BD-1, Human

ArtNr	Z02754-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 25 ug
Kategorie	Oncology Neuroscience Neuroinflammation By Cell Type Hematology Leukemia Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Migration & Invasion By Organ Heart & Blood Cancer
Typ	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Specific against	Human (Homo sapiens)
Purity	>98% by SDS-PAGE and HPLC analyses.
Sequence	GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02754-beta-Defensin_1_BD-1_Human, Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the ß-defensins by the pairing of their three disulfide bonds. To date, four human ß-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. ß-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The ß-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. ß-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. ß-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 5.0 KDa, a single non-glycosylated polypeptide chain containing 47 amino acids.</td></tr><tr><th>Purity</th><td colspan="7"> >98% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuBD-1 as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usingCD34+ dendritic cells, is less than 1000 ng/ml, corresponding to a specific activity of &
Similar products	beta-Defensin
Versandbedingung	Gekühlt
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Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usingCD34+ dendritic cells, is less than 1000 ng/ml, corresponding to a specific activity of ＞, 1.0 x 103 IU/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	Approximately 5.0 KDa, a single non-glycosylated polypeptide chain containing 47 amino acids.
Product Line	Cytokines
Manufacturer - Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usingCD34+ dendritic cells, is less than 1000 ng/ml, corresponding to a specific activity of ＞, 1.0 x 103 IU/mg.
Description	Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the ß-defensins by the pairing of their three disulfide bonds. To date, four human ß-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. ß-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The ß-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. ß-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. ß-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2µ, m filtered concentrated, solution in 20mM PB, pH 7.4, 130mM NaCl.
Endotoxin Level	Less than 0.2EU/ug of rHuBD-1 as determined by LAL method.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

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Menge: 1 mg

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