IFN-γ, Human

ArtNr	Z02915-100
Hersteller	GenScript
Menge	100 ug
Quantity options	1 mg 10 ug 100 ug 50 ug
Kategorie	Oncology Neuroscience Neuroinflammation By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Toxicity & Cytotoxicity Hypertension
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by reducing SDSPAGE.
Citations	Trinchieri, G.(2010) J Exp Med. 207:2053–63. Ealick, S.E. et al.(1991) Science. 252:698–702. Schroder, K. et al.(2004) J Leukoc Biol.75:163–89. Hu, X. et al. (2008) Immunol Rev. 226: 41–56. Wischhusen, J. et al.(2007) Semin Cancer Biol. 17:459–68.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02915_100-Interferon_gamma_Human, Human Interferon gamma (hIFN-gamma) is amacrophageactivating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma–induced inflammatory cascade summons a variety of immunerelated cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in, E. coli, is a nonglycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDSPAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7"> 17kDa, observed by reducing SDSPAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by reducing SDSPAGE.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <1 EU/ug, determined by LAL</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant human Interferon gamma (rhIFNgamma) remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhIFN-gamma should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Reference</th><td colspan="7">Trinchieri, G.(2010) J Exp Med. 207:2053–63. Ealick, S.E. et al.(1991) Science. 252:698–702. Schroder, K. et al.(2004) J Leukoc Biol.75:163–89. Hu, X. et al. (2008) Immunol Rev. 226: 41–56. Wischhusen, J. et al.(2007) Semin Cancer Biol. 17:459–68.</td></tr>
Similar products	Interferon-gamma
Versandbedingung	Gekühlt
Lieferbar
Specificity	ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	17kDa, observed by reducing SDSPAGE.
Product Line	Cytokines
Manufacturer - Specificity	ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.
Description	Human Interferon gamma (hIFN-gamma) is amacrophageactivating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma–induced inflammatory cascade summons a variety of immunerelated cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in, E. coli, is a nonglycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDSPAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<1 EU/ug, determined by LAL

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Menge: 100 ug

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