Flt-3L, Human

ArtNr	Z02926-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 10 ug 50 ug
Kategorie	Oncology Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Aging & Neurological Disorders By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Cell Metabolism Cardiovascular Research Myocardial Infarction Oxidative Stress Hypertension By Organ Colorectal Cancer Thyroid Cancer
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Sequence	Thr27-Pro185 (Accession # AAA17999)
Citations	1. Dong, J. et al. (2002). Cancer Biol Ther. 1:486-9. 2. Wodnar-Filipowicz, A. (2003). News Physiol Sci. 18:247-51. 3. Rosen, David. et al. (2010). PLoS ONE 5(10): e13543, 4. Lyman, S. et al. (1993). Cell 75, 1157-1167.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02926_1-Flt_3_Ligand_Flt_3L_Human,Fms-related tyrosine kinase 3 ligand (Flt3L), is growth fator stimulates the proliferation and differentiation of hematopoietic multipotent progenitors and promotes proliferation of NK cells and dendritic cell subgroups by combination with other growth factors. Flt3L is produced by T cells and stromal fibroblasts, and targeted various cells including hematopoietic stem cells, B cells, T cells, dendritic cells, and NK cells [1][2]. Flt3L binds to it cognate tyrosine kinase receptor Flt3 and activates JAK/STAT signaling pathway[3]. Flt3L is a hematopoietic four helical bundle cytokine with structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1) demonstrated four conserved cysteines and two glycosylation sites. Flt3L naturally as a non-disulfide-linked homodimer with multiple isoforms. The extracellular portion is approximately 160 amino acid residues in length and the cytoplasmic segment is approximately 20-30 amino acid residues in length[4]. </td></tr><tr><th>M.W.</th><td colspan="7"> Multiple bands between 18ca.22 kDa, observed by reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by SDS-PAGE and HPLC.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50, 1 x 106 units/mg</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Fms-related tyrosine kinase 3 ligand (Flt-3 Ligand), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhFlt-3L should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Thr27-Pro185 (Accession
Similar products	Flt-3
Versandbedingung	Gekühlt
Lieferbar
Specificity	ED50, 1 x 106 units/mg
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	Multiple bands between 18ca.22 kDa, observed by reducing SDS-PAGE.
Product Line	Growth Factors
Manufacturer - Specificity	ED50, 1 x 106 units/mg
Description	Fms-related tyrosine kinase 3 ligand (Flt3L), is growth fator stimulates the proliferation and differentiation of hematopoietic multipotent progenitors and promotes proliferation of NK cells and dendritic cell subgroups by combination with other growth factors. Flt3L is produced by T cells and stromal fibroblasts, and targeted various cells including hematopoietic stem cells, B cells, T cells, dendritic cells, and NK cells [1][2]. Flt3L binds to it cognate tyrosine kinase receptor Flt3 and activates JAK/STAT signaling pathway[3]. Flt3L is a hematopoietic four helical bundle cytokine with structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1) demonstrated four conserved cysteines and two glycosylation sites. Flt3L naturally as a non-disulfide-linked homodimer with multiple isoforms. The extracellular portion is approximately 160 amino acid residues in length and the cytoplasmic segment is approximately 20-30 amino acid residues in length[4].
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.

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