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4-1BB R/TNFRSF9, Human

4-1BB R/TNFRSF9, Human

ArtNr	Z02933-20
Hersteller	GenScript
Menge	20 ug
Quantity options	1 mg 20 ug 5 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Development By Cell Type Blastoma Carcinoma Peptides & Proteins Recombinant Proteins
Typ	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Specific against	Human (Homo sapiens)
Purity	>97% by SDS-PAGE and HPLC analyses.
Sequence	ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGG QRTCDICRQC KGVFRTRKEC SSTSNAECDC TPGFHCLGAG CSMCEQDCKQ GQELTKKGCK DCCFGTFNDQ KRGICRPWTN CSLDGKSVLV NGTKERDVVC GPSPADLSPG ASSVTPPAPA REPGHS
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02933_20-4_1BB_Receptor_TNFRSF9_Human, 4-1BB Receptor, also named TNFRSF9 is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 17.7 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids.</td></tr><tr><th>Purity</th><td colspan="7"> >97% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 1EU/ug of rHuTNFRSF9 as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The biologically active is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90% of inibition was seen using a concentration of 1ug for both 4-1BB Ligand and 4-1BB Receptor.</td></tr><tr><th>Storage</th><td colspan="7"> This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles. </td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized from a 0.2 um filtered concentrated solution in 10mM PB, pH 8.0, 150mM NaCl.</td></tr><tr><th>Reconstitution</th><td colspan="7"> We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <=-20C. Further dilutions should be made in appropriate buffered solutions.</td></tr><tr><th>Physical Appearance</th><td colspan="7"> Sterile Filtered White lyophilized (freeze-dried) powder.</td></tr><tr><th>Sequence</th><td colspan="7"> ERTRSLQDPC SNCPAGTFCD NNRNQICSPC PPNSFSSAGG QRTCDICRQC KGVFRTRKEC SSTSNAECDC TPGFHCLGAG CSMCEQDCKQ GQELTKKGCK DCCFGTFNDQ KRGICRPWTN CSLDGKSVLV NGTKERDVVC GPSPADLSPG ASSVTPPAPA REPGHS</td></tr>
Similar products	4-1BB
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Specificity	Fully biologically active when compared to standard. The biologically active is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90% of inibition was seen using a concentration of 1ug for both 4-
Manufacturer - Category	Proteins
Country of Origin	USA
Storage Conditions	This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Approximately 17.7 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids.
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	Fully biologically active when compared to standard. The biologically active is determined by its inhibitory effect of IL-8 production using human peripheral blood mononuclear cells. About 90% of inibition was seen using a concentration of 1ug for both 4-1BB Ligand and 4-1BB Receptor.
Description	4-1BB Receptor, also named TNFRSF9 is a member of the TNF superfamily of receptors. It is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <=-20C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 10mM PB, pH 8.0, 150mM NaCl.
Endotoxin Level	Less than 1EU/ug of rHuTNFRSF9 as determined by LAL method.

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Z02933-20-datasheet.pdf

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Menge: 20 ug

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Lieferung vsl. bis 17.07.2025

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