Description |
Granulocyte Colony-Stimulating Factor (G-CSF), contains internal disulfide bonds. Among the family of colony-stimulating factors, Granulocyte Colony Stimulating Factor (G-CSF) is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of Granulocyte Colony Stimulating Factor (G-CSF) can be induced by bacterial endotoxins, TNF, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of Granulocyte Colony Stimulating Factor (G-CSF). In epithelial, endothelial, and fibroblastic cells secretion of Granulocyte Colony Stimulating Factor (G-CSF) is induced by Interleukin-17. Recombinant, human Granulocyte Colony-Stimulating Factor (rhG-CSF), produced in E. coliis a single non-glycosylated polypeptide chain containing 175amino acids. A fully biologically active molecule, rhG-CSF is obtained by proprietary chromatographic techniques at GenScript, with an apparent molecular mass of 18.8kDa analyzed by reducing SDS-PAGE. |
Storage |
Lyophilized recombinant, human Granulocyte Colony-Stimulating Factor (rhG-CSF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-CSF should be stable up to 2 weeks at 4C or up to 3 months at -20C. |