B-cell activating factor (BAFF), Human

Hersteller GenScript
Kategorie Produkte / Proteins
Typ Proteins
Specific against Human
Menge 50.0ug 
ArtNr Z02976-50
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Product Line
Cytokines, Chemokines & Growth Factors
Description
B-cell activating factor, also known as, BAFF, TALL-1, TNAK, and zTNF4, is a member of theTNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4+ T cells, thymus and peripheral blood leukocytes.
M.W.
17kDa, observed by non-reducing SDS-PAGE.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Endotoxin Level
<0.2 EU/ug, determined by LAL method.
Specific Activity
ED50 5.0 x 104 units/mg.
Storage
Lyophilized recombinant, human B-Cell Activating Factor (BAFF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rh-BAFF should be stable up to 1 week at 4C or up to 2 months at -20C.
Formulation
Lyophilized after extensive dialysis against PBS.
Reconstitution
Reconstituted in ddH2O or PBS at 100 ug/ml.
Sequence
Ala134-Leu285 (Accession # Q9Y275).
Note
For research use only
Menge: 50.0ug 
Lieferbar: In stock
Listenpreis: 208,90 €
Preis: 208,90 €
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