Neurotrophin-4 (NT-4), Human

Lyophilized recombinant, human Neurotrophin-4 (rhNT-4), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhNT-4 should be stable up to 2 weeks at 4C or up to 3 months at -20C.

Cytokines, Chemokines & Growth Factors

Neurotrophin-4 (NT-4) , also known as NT-5, is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52% aa sequence identity with human beta-NGF, BDNF, and NT-3.Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant, human Neurotrophin-4 (rhNT-4), produced in, E.coli, is a noncovalently linked homodimer containing two non-glycosylated polypeptide chains of 131 amino acids. A fully biologically active molecule, rhNT-4 has a molecular mass of 28.1kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

Lyophilized after extensive dialysis against 50mM acetic acid.

For research use only