HDAC1, Flag-His, Human

USA

-65

HDAC1 is a member of the histone deacetylase family. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Recombinant human HDAC1 with flag-his-tag produced in Sf9 Cell is a single, non-glycosylated polypeptide chain containing 496 amino acids. A fully biologically active molecule, HDAC1 has a molecular mass of 56.9 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.