Histone deacetylase 3, human

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HDAC3 belongs to the histone deacetylase/ acuc/apha family. In humans HDAC3 is encoded by the HDAC3 gene. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene
The Nuclear receptor co-repressor 2 (NcoR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NcoR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NcoR2 assists nuclear receptors in the down regulation of target gene expression. NcoR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).
Recombinant human HDAC 3 / NcoR2 produced in Sf9 Cell is a co-expression, non-glycosylated complex containing 434/316 amino acids. A fully biologically active molecule, human HDAC3 / NcoR2 has a molecular mass of 49.7/37.6 kDa and is obtained by proprietary chromatographic techniques at GenScript.