HDAC4, GST, Human

USA

-65

HDAC4 is a member of the histone deacetylase family.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Recombinant human HDAC4 with GST tag produced in Sf9 Cell is a single, non-glycosylated polypeptide chain containing 678 amino acids. A fully biologically active molecule, HDAC4 has a molecular mass of 74.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.