Glia Maturation Factor beta (GMF-beta), Human

Hersteller GenScript
Kategorie
Typ Proteins
Specific against Human
Menge 10ug
ArtNr Z03200-10
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Glia Maturation Factor beta (GMF-beta) is a 17 kDa brain specific protein that belongs to the ADF/cofilin superfamily. It is a neurotrophin that induces maturation of neurons and glial cells. Unlike other neurotrophins, GMF-beta lacks a leader sequence and can be phosphorylated by protein kinase A and protein kinase C suggesting its role in signal transduction. GMF-beta is a prominent mediator of inflammation in the central nervous system and can activate several inflammation-related genes such as tumor necrosis factor-alpha and interleukin-1beta. Researchers have shown there are significantly higher levels of GMF-beta protein in all the effected regions of Alzheimer’s disease (AD) brains suggesting an important role of GMF-beta in AD pathogenesis
Recombinant human Glia Maturation Factor beta (rhGMF-beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 142 amino acids. rhGMF-beta has a molecular mass of 16.7kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Line
PL313_Neurotrophines
Storage Temperature
-65
Shipping Temperature
4
Menge: 10ug
Lieferbar: In stock
Listenpreis: 111,87 €
Preis: 111,87 €
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