Hersteller |
GenScript
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Mouse |
Format |
Sterile Filtered White lyophilized (freeze-dried) powder. |
Menge |
10ug |
ArtNr |
Z02769-10 |
Targets |
IL11, IL6, IL4, CD2 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Specificity |
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of the proliferation of murine T11 was found to be less than 2.0 ng/ml, corresponding to a specific activity of 5.0x105 IU/mg. |
Description |
Interleukin 11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1ª-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell. |
Endotoxin Level |
Less than 0.2EU/ug of rMuIL-11 as determined by LAL method. |
Formulation |
Lyophilized from a 0.2µ, m filtered solution in PBS, pH 7.4. |
M.W. |
Approximately 19.1 kDa, a single non-glycosylated polypeptide chain containing 179 amino acids. |
Product Line |
Cytokine, Chemokines & Growth Factors |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°, C. Further dilutions should be made in appropriate buffered solutions. |
Storage |
This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles. |
Usage |
This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
Product Origin |
USA |
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