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TNF-α, Mouse (P. pastoris-expressed)

TNF-α, Mouse (P. pastoris-expressed)

ArtNr	Z02918-100
Hersteller	GenScript
Menge	100 ug
Quantity options	1 mg 100 ug 20 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Proliferation Hypertension
Typ	Proteins
Specific against	Mouse (Murine, Mus musculus)
Purity	> 95% as analyzed by reducing SDS-PAGE.
Sequence	Ser84-Leu235 (accession number:P06804).
Citations	1. Friedmann, E. et al. (2006) Nat Cell Biol. 8: 843-48. 2. Pocsik, E. et al. (1995)JInflamm. 45: 152-60. 3. Hlodan, R. et al. (1995) Eur JBiochem. 231: 381-87. 4. Hehlgans, T. and K. Pfeffer (2005)Immunology 115:1-20.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02918_100-TNF_Mouse, Sharing 79% sequence identity with human Tumor Necrosis Factor-alpha (hTNF-alpha), mouse Tumor Necrosis Factor-alpha (mTNF-alpha), is a cytokine mainly expressed by immune cells [1]. A type II transmembrane protein, TNF-alpha is further proteolytically processed to a soluble form [2]. The trimeric active TNF-alpha[3] then exerts its diverse biological properties including gapoptosis, inflammation, autoimmunity and cell proliferation by binding to TNF Receptor 1 and 2 [4]. Recombinant, mouse Tumor Necrosis Factor-alpha (rmTNF-alpha), produced in, P.pastoris, is a fully biologically active polypeptide chain of 152 amino acids with a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7"> 17kDa, observed by reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by reducing SDS-PAGE.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <1 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50 1 x 108units/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, mouse Tumor Necrosis Factor-alpha (rmTNF-alpha), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rmTNF-alphashould be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ser84-Leu235 (accession number:P06804).</td></tr><tr><th>Reference</th><td colspan="7">1. Friedmann, E. et al. (2006) Nat Cell Biol. 8: 843-48. 2. Pocsik, E. et al. (1995)JInflamm. 45: 152-60. 3. Hlodan, R. et al. (1995) Eur JBiochem. 231: 381-87. 4. Hehlgans, T. and K. Pfeffer (2005)Immunology 115:1-20.</td></tr>
Similar products	TNF-alpha
Versandbedingung	Gekühlt
Lieferbar
Specificity	ED50 1 x 108units/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	17kDa, observed by reducing SDS-PAGE.
Product Line	Cytokines
Manufacturer - Specificity	ED50 1 x 108units/mg.
Description	Sharing 79% sequence identity with human Tumor Necrosis Factor-alpha (hTNF-alpha), mouse Tumor Necrosis Factor-alpha (mTNF-alpha), is a cytokine mainly expressed by immune cells [1]. A type II transmembrane protein, TNF-alpha is further proteolytically processed to a soluble form [2]. The trimeric active TNF-alpha[3] then exerts its diverse biological properties including gapoptosis, inflammation, autoimmunity and cell proliferation by binding to TNF Receptor 1 and 2 [4]. Recombinant, mouse Tumor Necrosis Factor-alpha (rmTNF-alpha), produced in, P.pastoris, is a fully biologically active polypeptide chain of 152 amino acids with a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<1 EU/ug, determined by LAL method.

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Menge: 100 ug

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Lieferung vsl. bis 07.08.2025