IL-22, Mouse

USA

-80°C

Interleukin-22 (IL-22) is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequence, but differ in their biological function. IL-22 is produced by T lymphocytes, and can inhibit IL-4 production by Th2 cells and induce acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-ß/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. By binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains, IL-22 specifically targets cells of epithelial origin where it induces pro-inflammatory activities.
Recombinant mouse Interleukin-22 (rmIL-22) produced in CHO cells, is a polypeptide chain containing 146 amino acids. It has a molecular mass of 20ca.30 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.