VEGF164, Mouse (P. pastoris-expressed)

Vascular Endothelial Growth Factor (VEGF), is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors, fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant, mouse Vascular Endothelial Growth Factor A164 (rmVEGF-A164), produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rmVEGF-A164 has a molecular mass of 39kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript

Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0.

Cytokine, Chemokines & Growth Factors

Lyophilized, recombinant mouse Vascular Endothelial Growth Factor A164 (rmVEGF-A164) remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rmVEGF-A164 should be stable up to 4 week at 4C or up to 6 months at -20C.

Growth Factors