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GRO-α/KC/CXCL1, Mouse

GRO-α/KC/CXCL1, Mouse

ArtNr	Z02899-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 20 ug
Kategorie	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Status Necrosis Cell Migration & Invasion By Organ Thyroid Cancer
Typ	Proteins
Specific against	Mouse (Murine, Mus musculus)
Purity	>97% by SDS-PAGE and HPLC analyses.
Sequence	APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02899_1-GRO_alpha_KC_CXCL1_Murine, KC/GRO/CXCL1 coded by CXCL1 gene at chromosome 5 is approximately 63% identity to that of mouse MIP2. KC is also approximately 60% identical to the human GROs. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 7.8kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.</td></tr><tr><th>Purity</th><td colspan="7"> >97% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rMuKC/GRO/CXCL1 as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human CXCR2 transfected BaF3 murine proB cells is less than 300 ng/ml, corresponding to a specific activity of, >3.3 × 103 IU/mg.</td></tr><tr><th>Storage</th><td colspan="7"> This lyophilized preparation is stable at 2-8C, but should be kept at -20Cfor long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.</td></tr><tr><th>Reconstitution</th><td colspan="7"> We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.</td></tr><tr><th>Sequence</th><td colspan="7"> APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK</td></tr>
Similar products	GRO-alpha/
Lieferbar
Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human CXCR2 transfected BaF3 murine proB cells is less than 300 ng/ml, corresponding to a specific activity of, >3.3 x 103 IU/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Storage Conditions	This lyophilized preparation is stable at 2-8C, but should be kept at -20Cfor long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Approximately 7.8kDa, a single non-glycosylated polypeptide chain containing 72 amino acid residues.
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human CXCR2 transfected BaF3 murine proB cells is less than 300 ng/ml, corresponding to a specific activity of, >3.3 x 103 IU/mg.
Description	KC/GRO/CXCL1 coded by CXCL1 gene at chromosome 5 is approximately 63% identity to that of mouse MIP2. KC is also approximately 60% identical to the human GROs. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
Endotoxin Level	Less than 0.2EU/ug of rMuKC/GRO/CXCL1 as determined by LAL method.

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Z02899-1.pdf

Z02899-1-datasheet.pdf

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