Batroxobin (BX/SVTLE), Reptile

Hersteller GenScript
Kategorie Produkte / Proteins
Typ Proteins
Specific against other
Menge 50ug 
ArtNr Z02963-50
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Product Line
Others
Description
Batroxobin is a serine protease derived from the venom of Bothrops atrox. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A (alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets.
M.W.
A single, glycosylated, polypeptide chain containing 231 amino acids, and having a molecular mass of approximately 28, 000ca.33, 000.
Purity
>97% by SDS-PAGE and HPLC analyses.
Endotoxin Level
Less than 0.5EU/mg of rRpBX/SVTLE as determined by LAL method.
Specific Activity
Fully biologically active when compared to standard. The biologically activity of rRpBX is no less than 500KU/mg (Klobusitzky Unit). One KU is defined as the amount of enzyme which coagulates standard human plasma incubated at 37 C in vitro within 60+/-20 seconds.
Storage
This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.
Formulation
Lyophilized from a 0.2um filtered concentrated sodium acetate buffer solution.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <=-20C. Further dilutions should be made in appropriate buffered solutions.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
VIGGDECDIN EHPFLAFMYY SPRYFCGMTL INQEWVLTAA HCNRRFMRIHLGKHAGSVAN YDEVVRYPKE KFICPNKKKN VITDKDIMLI RLDRPVKNSEHIAPLSLPSN PPSVGSVCRI MGWGAITTSE DTYPDVPHCA NINLFNNTVC REAYNGLPAK TLCAGVLQGG IDTCGGDSGG PLICNGQFQG ILSWGSDPCA EPRKPAFYTK VFDYLPWIQS IIAGNKTATC P
Menge: 50ug 
Lieferbar: Out of stock
Listenpreis: 207,03 €
Preis: 207,03 €
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