Interleukin 1 beta (IL-1 beta), Murine

Hersteller GenScript
Kategorie Produkte / Proteins
Typ Proteins
Specific against Murine
Menge 1mg
ArtNr Z02988-1
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Product Line
Cytokines, Chemokines & Growth Factors
Description
Interleukin-1 (IL-1), is a family of cytokines that play a central role in the regulation of immune and inflammatory responses to infections or sterile insults. IL-1alpha and IL-1beta are the first two members discovered in this family, which are the products of distinct genes recognizing the same cell surface receptors. IL-1alpha and IL-1beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1beta is interleukin 1beta-converting enzyme (ICE)/caspase-1. Mature human and mouse IL-1beta share approximately 75% amino acid sequence identity where human IL-1beta has been found to be active on murine cell lines. GenScript Interleukin (IL)-1beta, murine, produced in, CHO, cells, is a non-glycosylated polypeptide chain containing 152 amino acids and having a molecular mass of 17, 400 Da.
M.W.
17.4 kDa, observed by non-reducing SDS-PAGE.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Endotoxin Level
<0.2 EU/ug, determined by LAL method.
Specific Activity
ED50, 1x108 units/mg.
Storage
Lyophilized recombinant, Murine Interleukin 1 beta (IL-1 beta), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rmIL-1beta should be stable up to 1 week at 4C or up to 2 months at -20C.
Formulation
Lyophilized after extensive dialysis against PBS.
Reconstitution
Reconstituted in ddH2O or PBS at 100 ug/ml.
Sequence
Val118-Ser269 (Accession # P10749).
Note
For research use only
Menge: 1mg
Lieferbar: In stock
Listenpreis: 1.634,60 €
Preis: 1.634,60 €
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