IL-9, Mouse

USA

-80°C

Interleukin 9, also known as IL9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
Recombinant Mouse IL-9 produced in HEK293 cells is a polypeptide chain containing 146 amino acids. A fully biologically active molecule, rmIL-9 has a molecular mass of 30-35 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.