MOUSE ANTI HUMAN CD169

GWB-21CD74

IgG1

Phosphate buffered saline pH7. 4

Human Rhinovirus (HRV14) treated monocyte-derived dendritic cells.

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes including granulocytes monocytes natural killer cells B-cells and CD8 T-cells. Preferentially binds to alpha-2 3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis. Subcellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue specificityExpressed by macrophages in various tissues. High levels are found in spleen lymph node perivascular macrophages in brain and lower levels in bone marrow liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Structure and expression of human fibroblast growth factor-10. \" Emoto H. Tagashira S. Mattei M. -G. Yamasaki M. Hashimoto G. Katsumata T. Negoro T. Nakatsuka M. Birnbaum D. Coulier F. Itoh N. J. Biol. Chem. 272:23191-23194(1997) [PubMed: 9287324] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. [2] \" Cutaneous wound healing by keratinocyte growth factor 2. \" Jimenez P. A. Gruber J. R. Liu B. Feng P. Florence C. Blunt A. Huddleston K. A. Teliska M. Alfonso P. Coleman T. A. Ornitz D. M. Dillon P. A. Duan R. D. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. [3] Zhang Y. Zhang B. Zhou Y. Peng X. Yuan J. Qiang B. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [5] NIEHS SNPs programSubmitted (APR-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [7] \" The fibroblast growth factor binding protein is a novel interaction partner of FGF-7 FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. \" Beer H. -D. Bittner M. Niklaus G. Munding C. Max N. Goppelt A. Werner S. Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]Cited for: INTERACTION WITH FGFBP1. [8] \" Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. \" Yeh B. K. Igarashi M. Eliseenkova A. V. Plotnikov A. N. Sher I. Ron D. Aaronson S. A. Mohammadi M. Proc. Natl. Acad. Sci. U. S. A. 100:2266-2271(2003) [PubMed: 12591959] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2. [9] \" Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. \" Entesarian M. Matsson H. Klar J. Bergendal B. Olson L. Arakaki R. Hayashi Y. Ohuchi H. Falahat B. Bolstad A. I. Jonsson R. Wahren-Herlenius M. Dahl N. Nat. Genet. 37:125-127(2005) [PubMed: 15654336] [Abstract]Cited for: INVOLVEMENT IN ALSG. [10] \" LADD syndrome is caused by FGF10 mutations. \" Milunsky J. M. Zhao G. Maher T. A. Colby R. Everman D. B. Clin. Genet. 69:349-354(2006) [PubMed: 16630169] [Abstract]Cited for: VARIANT LADDS ARG-156.