Antibodies

MOUSE ANTI HUMAN CD169

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Human
Applications IP
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314621
Available
Genway ID:
GWB-21CD74
Specificity:
CD169
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Human Rhinovirus (HRV14) treated monocyte-derived dendritic cells.
Specificity:
Specifically recognises human CD169 otherwise known as Sialoadhesin (Sn) a type I transmembrane glycoprotein and prototypic member of the Siglec (sialic acid binding Ig-like lectin) family designated Siglec-1. CD169 is a macrophage-restricted interaction molecule which binds to sialylated ligands on haematopoietic cells including neutrophils NK cells monocytes a subset of CD8+ T cells and B cells through recognition of sialic acid in the alpha-2 3- glycosidic linkage. CD169 is highly expressed by dendritic cells and on stromal macrophages in the spleen bone marrow and lymph nodes and to a lesser extent in liver lungs and gut and studies have shown high expression of CD169 on macrophages in the inflammatory conditions rheumatoid arthritis and atherosclerosis. Clone 7-239 completely inhibits erythrocyte rosetting around Sn+ transductants. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes including granulocytes monocytes natural killer cells B-cells and CD8 T-cells. Preferentially binds to alpha-2 3-linked sialic acid By similarity. Binds to SPN/CD43 on T-cells By similarity. May play a role in hemopoiesis. Subcellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue specificityExpressed by macrophages in various tissues. High levels are found in spleen lymph node perivascular macrophages in brain and lower levels in bone marrow liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Structure and expression of human fibroblast growth factor-10. \" Emoto H. Tagashira S. Mattei M. -G. Yamasaki M. Hashimoto G. Katsumata T. Negoro T. Nakatsuka M. Birnbaum D. Coulier F. Itoh N. J. Biol. Chem. 272:23191-23194(1997) [PubMed: 9287324] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. [2] \" Cutaneous wound healing by keratinocyte growth factor 2. \" Jimenez P. A. Gruber J. R. Liu B. Feng P. Florence C. Blunt A. Huddleston K. A. Teliska M. Alfonso P. Coleman T. A. Ornitz D. M. Dillon P. A. Duan R. D. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. [3] Zhang Y. Zhang B. Zhou Y. Peng X. Yuan J. Qiang B. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [5] NIEHS SNPs programSubmitted (APR-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [7] \" The fibroblast growth factor binding protein is a novel interaction partner of FGF-7 FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. \" Beer H. -D. Bittner M. Niklaus G. Munding C. Max N. Goppelt A. Werner S. Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]Cited for: INTERACTION WITH FGFBP1. [8] \" Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. \" Yeh B. K. Igarashi M. Eliseenkova A. V. Plotnikov A. N. Sher I. Ron D. Aaronson S. A. Mohammadi M. Proc. Natl. Acad. Sci. U. S. A. 100:2266-2271(2003) [PubMed: 12591959] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2. [9] \" Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. \" Entesarian M. Matsson H. Klar J. Bergendal B. Olson L. Arakaki R. Hayashi Y. Ohuchi H. Falahat B. Bolstad A. I. Jonsson R. Wahren-Herlenius M. Dahl N. Nat. Genet. 37:125-127(2005) [PubMed: 15654336] [Abstract]Cited for: INVOLVEMENT IN ALSG. [10] \" LADD syndrome is caused by FGF10 mutations. \" Milunsky J. M. Zhao G. Maher T. A. Colby R. Everman D. B. Clin. Genet. 69:349-354(2006) [PubMed: 16630169] [Abstract]Cited for: VARIANT LADDS ARG-156.
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Price: €326.19
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