MOUSE ANTI HUMAN DECTIN-1

DECTIN-1

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises human Dectin-1 also known as beta-glucan receptor (& #223; GR) a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans glucose polymers that form cell-wall components or exopolymers of yeasts fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial yeast viral and protozoan infections as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (& #223; GR-A and & #223; GR-B) and several minor isoforms. & #223; GR-A and & #223; GR-B differs by the presence and absence respectively of a stalk region.