Antibodies

MOUSE ANTI HUMAN DECTIN-1

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314795
Available
Genway ID:
GWB-80B177
Specificity:
DECTIN-1
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
NIH3T3 cells expressing full length Beta-glucan receptor.
Specificity:
Recognises human Dectin-1 also known as beta-glucan receptor (& #223; GR) a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans glucose polymers that form cell-wall components or exopolymers of yeasts fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial yeast viral and protozoan infections as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (& #223; GR-A and & #223; GR-B) and several minor isoforms. & #223; GR-A and & #223; GR-B differs by the presence and absence respectively of a stalk region.
Specificity:
(clone GE2) Recognises both of these isoforms. Clone GE2 could be used to inhibit receptor function. Recommended for functional assays. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Discount: -10.0%
Price: €293.57
You save: €32.62
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