MOUSE ANTI HUMAN CD86:FITC

GWB-B32334

IgG1

Phosphate buffered saline pH7. 2

Human peripheral blood lymphocytes

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters and thus acts as a negative regulator of T-cell activation. Subunit structureInteracts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. Ref. 11Ref. 12Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityExpressed by activated B-lymphocytes and monocytes. Post-translational modificationPolyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.