MOUSE ANTI HUMAN CD25:RPE-Cy5

CD25

Purified IgG prepared by affinity chromatography

Receptor for interleukin-2. Subunit structureNon-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer an intermediate affinity monomer (beta subunit) and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Subcellular locationMembrane; Single-pass type I membrane protein. Involvement in diseaseGenetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10) [MIM:601942]. Sequence similaritiesContains 2 Sushi (CCP/SCR) domains. [1] \" Characterization of beta-R1 a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. \" Rani M. R. S. Foster G. R. Leung S. Leaman D. Stark G. R. Ransohoff R. M. J. Biol. Chem. 271:22878-22884(1996) [PubMed: 8798467] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Astrocyte. [2] \" A genetic selection for isolating cDNAs encoding secreted proteins. \" Jacobs K. A. Collins-Racie L. A. Colbert M. Duckett M. Golden-Fleet M. Kelleher K. Kriz R. LaVallie E. R. Merberg D. Spaulding V. Stover J. Williamson M. J. McCoy J. M. Gene 198:289-296(1997) [PubMed: 9370294] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood monocyte. [3] \" Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. \" Cole K. E. Strick C. A. Paradis T. J. Ogborne K. T. Loetscher M. Gladue R. P. Lin W. Boyd J. G. Moser B. Wood D. E. Sahagan B. G. Neote K. J. Exp. Med. 187:2009-2021(1998) [PubMed: 9625760] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal astrocyte. [4] \" Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). \" Tensen C. P. Flier J. van der Raaij-Helmer E. M. H. Sampat-Sardjoepersad S. van der Schors R. C. Leurs R. Scheper R. J. Boorsma D. M. Willemze R. J. Invest. Dermatol. 112:716-722(1999) [PubMed: 10233762] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PROTEIN SEQUENCE OF 22-38 MASS SPECTROMETRY. Tissue: Keratinocyte. [5] \" Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1). \" Laich A. M. Meyer M. Werner E. R. Werner-Felmayer G. J. Interferon Cytokine Res. 19:505-513(1999) [PubMed: 10386863] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Myeloma. [6] \" Genomic organization sequence and transcriptional regulation of the human CXCL 11 gene. \" Tensen C. P. Flier J. Rampersad S. Sampat-Sardjoepersad S. Scheper R. J. Boorsma D. M. Willemze R. Biochim. Biophys. Acta 1446:167-172(1999) [PubMed: 10395932] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Keratinocyte. [7] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [8] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow Brain and Liver. [9] \" The human gene encoding SCYB9B a putative novel CXC chemokine maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10). \" Erdel M. Laich A. Utermann G. Werner E. R. Werner-Felmayer G. Cytogenet. Cell Genet. 81:271-272(1998) [PubMed: 9730616] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 28-84. [10] \" Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. \" Loos T. Mortier A. Gouwy M. Ronsse I. Put W. Lenaerts J. P. Van Damme J. Proost P. Blood 112:2648-2656(2008) [PubMed: 18645041] [Abstract]Cited for: CITRULLINATION AT ARG-27.