RAT ANTI MOUSE CD25:FITC

CD25

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

B6. 1 CTL cell line

Receptor for interleukin-2. Subunit structureNon-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer an intermediate affinity monomer (beta subunit) and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 2 Sushi (CCP/SCR) domains. 1. Martinon F. et al (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-74. 2. Zhivotovsky B. et al (2005) Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 331:859-67. 3. Wolf B. B. et al (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 274:20049-52. 4. Fernandes-Alnemri T. et al (1995) Mch2 a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 55:2737-42. [1] \" Mch2 a new member of the apoptotic Ced-3/Ice cysteine protease gene family. \" Fernandes-Alnemri T. Litwack G. Alnemri E. S. Cancer Res. 55:2737-2742(1995) [PubMed: 7796396] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). Tissue: T-cell. [2] NIEHS SNPs programSubmitted (MAR-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT SER-182. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Tissue: Lung. [4] \" The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. \" Srinivasula S. M. Fernandes-Alnemri T. Zangrilli J. Robertson N. Armstrong R. C. Wang L. Trapani J. A. Tomaselli K. J. Litwack G. Alnemri E. S. J. Biol. Chem. 271:27099-27106(1996) [PubMed: 8900201] [Abstract]Cited for: PROTEOLYTIC PROCESSING. Tissue: Lymphocyte. [5] \" Regulation of caspase-6 and FLIP by the AMPK family member ARK5. \" Suzuki A. Kusakai G. Kishimoto A. Shimojo Y. Miyamoto S. Ogura T. Ochiai A. Esumi H. Oncogene 23:7067-7075(2004) [PubMed: 15273717] [Abstract]Cited for: ENZYME REGULATION PHOSPHORYLATION AT SER-257 MUTAGENESIS OF SER-257. [6] Colinge J. Superti-Furga G. Bennett K. L. Submitted (OCT-2008) to UniProtKBCited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].