RAT ANTI MOUSE CD279

CD279

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises mouse CD279 a 55kD cell surface protein which is a member of the CD28/CTLA-4 family otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279 an immunoinhibitory receptor plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family B7-H1 (PD-L1) and B7-DC (PD-L2) have been identified as the ligands for CD279. Antibodies produced by clone RMP1-30 do not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)