Antibodies

RAT ANTI MOUSE CD279

Manufacturer GENWAY
Category
Type Antibody
Specific against Mouse
Amount 0.1 mg
Host Rat
ArtNr 20-783-314608
Available
Genway ID:
GWB-7DED73
Specificity:
CD279
Isotype:
IgG2b
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1 mg/ml
Immunogen:
PD-1 transferred BHK cells
Specificity:
Recognises mouse CD279 a 55kD cell surface protein which is a member of the CD28/CTLA-4 family otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279 an immunoinhibitory receptor plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family B7-H1 (PD-L1) and B7-DC (PD-L2) have been identified as the ligands for CD279. Antibodies produced by clone RMP1-30 do not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
Possible cell death inducer in association with other factors. Subunit structureMonomer. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityThymus. Developmental stageInduced at programmed cell death. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
Amount: 0.1 mg
Available: In stock
Listprice: €242.60
Discount: -10.0%
Price: €218.34
You save: €24.26
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