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RAT ANTI MOUSE CD279

RAT ANTI MOUSE CD279

Manufacturer	GENWAY
Category	Antibodies Primary Antibodies
Type	Antibody
Specific against	Mouse
Amount	0.1 mg
Host	Rat
Item no.	20-783-314608
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-7DED73
Specificity:	CD279
Isotype:	IgG2b
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1 mg/ml
Immunogen:	PD-1 transferred BHK cells
Specificity:	Recognises mouse CD279 a 55kD cell surface protein which is a member of the CD28/CTLA-4 family otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279 an immunoinhibitory receptor plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family B7-H1 (PD-L1) and B7-DC (PD-L2) have been identified as the ligands for CD279. Antibodies produced by clone RMP1-30 do not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells. Recommended Negative Controls: RAT IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:	Possible cell death inducer in association with other factors. Subunit structureMonomer. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityThymus. Developmental stageInduced at programmed cell death. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 5/30/2024