RAT ANTI MOUSE CD274

CD274

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Detects mouse CD274 also known as B7-H1 and PD-1L a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells and is induced on activated T-cells B-cells endothelial cells and epithelial cells in response to Interferons alpha beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naï ve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate early T cell priming and differentiation. Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection as well as in many autoimmune diseases and cancers. Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)