RAT ANTI MOUSE CD8 ALPHA:FITC

GWB-3AD31C

IgG2a

Phosphate buffered saline pH7. 2

Mouse thymus or spleen.

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. Subunit structureIn general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Subcellular locationMembrane; Single-pass type I membrane protein. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. \" Poncz M. Surrey S. Larocco P. Weiss M. J. Rappaport E. F. Conway T. M. Schwartz E. Blood 69:219-223(1987) [PubMed: 3098319] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. \" Eisman R. Surrey S. Ramachandran B. Schwartz E. Poncz M. Blood 76:336-344(1990) [PubMed: 1695112] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] \" Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. \" Zhang C. Thornton M. A. Kowalska M. A. Sachis B. S. Feldman M. Poncz M. McKenzie S. E. Reilly M. P. Blood 98:610-617(2001) [PubMed: 11468158] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [4] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Ebert L. Schick M. Neubert P. Schatten R. Henze S. Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [5] \" Generation and annotation of the DNA sequences of human chromosomes 2 and 4. \" Hillier L. W. Graves T. A. Fulton R. S. Fulton L. A. Pepin K. H. Minx P. Wagner-McPherson C. Layman D. Wylie K. Sekhon M. Becker M. C. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Kremitzki C. Oddy L. Du H. Sun H. Bradshaw-Cordum H. Ali J. Carter J. Cordes M. Harris A. Isak A. van Brunt A. Nguyen C. Du F. Courtney L. Kalicki J. Ozersky P. Abbott S. Armstrong J. Belter E. A. Caruso L. Cedroni M. Cotton M. Davidson T. Desai A. Elliott G. Erb T. Fronick C. Gaige T. Haakenson W. Haglund K. Holmes A. Harkins R. Kim K. Kruchowski S. S. Strong C. M. Grewal N. Goyea E. Hou S. Levy A. Martinka S. Mead K. McLellan M. D. Meyer R. Randall-Maher J. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Shah N. Swearengen-Shahid S. Snider J. Strong J. T. Thompson J. Yoakum M. Leonard S. Pearman C. Trani L. Radionenko M. Waligorski J. E. Wang C. Rock S. M. Tin-Wollam A. -M. Maupin R. Latreille P. Wendl M. C. Yang S. -P. Pohl C. Wallis J. W. Spieth J. Bieri T. A. Berkowicz N. Nelson J. O. Osborne J. Ding L. Meyer R. Sabo A. Shotland Y. Sinha P. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Jones T. A. She X. Ciccarelli F. D. Izaurralde E. Taylor J. Schmutz J. Myers R. M. Cox D. R. Huang X. McPherson J. D. Mardis E. R. Clifton S. W. Warren W. C. Chinwalla A. T. Eddy S. R. Marra M. A. Ovcharenko I. Furey T. S. Miller W. Eichler E. E. Bork P. Suyama M. Torrents D. Waterston R. H. Wilson R. K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [7] \" Isolation crystallization and primary amino acid sequence of human platelet factor 4. \" Hermodson M. Schmer G. Kurachi K. J. Biol. Chem. 252:6276-6279(1977) [PubMed: 893407] [Abstract]Cited for: PROTEIN SEQUENCE OF 32-101. [8] \" Amino acid sequence of human platelet factor 4. \" Deuel T. F. Keim P. S. Farmer M. Heinrikson R. L. Proc. Natl. Acad. Sci. U. S. A. 74:2256-2258(1977) [PubMed: 267922] [Abstract]Cited for: PROTEIN SEQUENCE OF 32-101. [9] \" Primary structure of human platelet factor 4. \" Walz D. A. Wu V. Y. de Lamo R. Dene H. McCoy L. E. Thromb. Res. 11:893-898(1977) [PubMed: 601757] [Abstract]Cited for: PROTEIN SEQUENCE OF 32-101. [10] \" Complete covalent structure of human platelet factor 4. \" Morgan F. J. Begg G. S. Chesterman C. N. Thromb. Haemost. 42:1652-1660(1980) [PubMed: 6445090] [Abstract]Cited for: PROTEIN SEQUENCE OF 32-101.