RAT ANTI MOUSE INTERLEUKIN-6:Azide Free

IL-6

Purified IgG prepared by affinity chromatography on protein G

Is specific for mouse IL-6 (interleukin-6) a multifunctional pro-inflammatory cytokine secreted by activated T cells macrophages endothelial cells fibroblasts and osteoblasts which acts as the principle inducer of the acute phase response in the liver. IL-6 signals through a membrane bound receptor complex consisting of the ligand-binding IL-6Ra chain (CD126) and the signal-transducing component gp130 (CD130) but can also stimulate cells expressing gp130 through a soluble IL-6R. IL-6 has been shown to stimulate B cell differentiation and subsequent immunoglobulin production promote hybridoma growth as well as regulating bone metabolism and stimulating energy mobilisation in muscle and fatty tissue. Clone 6B4 IGH 54 can be used to neutralise the activity of 50pg/ml of recombinant mouse IL-6 by > 95% in a functional assay. Recommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)