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RAT ANTI MOUSE INTERLEUKIN-6:Azide Free

RAT ANTI MOUSE INTERLEUKIN-6:Azide Free

Item no.	20-783-314737
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Hematology Leukemia Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-FABF10
Similar products	20-783-314737
Available
Genway ID:	GWB-FABF10
Specificity:	IL-6
Isotype:	IgG1
Preparation:	Purified IgG prepared by affinity chromatography on protein G
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		None presentApprox. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:	Natural partially purified mouse IL-6.
Specificity:	Is specific for mouse IL-6 (interleukin-6) a multifunctional pro-inflammatory cytokine secreted by activated T cells macrophages endothelial cells fibroblasts and osteoblasts which acts as the principle inducer of the acute phase response in the liver. IL-6 signals through a membrane bound receptor complex consisting of the ligand-binding IL-6Ra chain (CD126) and the signal-transducing component gp130 (CD130) but can also stimulate cells expressing gp130 through a soluble IL-6R. IL-6 has been shown to stimulate B cell differentiation and subsequent immunoglobulin production promote hybridoma growth as well as regulating bone metabolism and stimulating energy mobilisation in muscle and fatty tissue. Clone 6B4 IGH 54 can be used to neutralise the activity of 50pg/ml of recombinant mouse IL-6 by > 95% in a functional assay. Recommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells T-cells hepatocytes hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance By similarity. Subcellular locationSecreted. Sequence similaritiesBelongs to the IL-6 superfamily.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/30/2025

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