HAMSTER ANTI MOUSE CD178:FITC

GWB-6E28F3

IgGSpecies Cross Reactivity: Reacts with: RatN. B. Antibody reactivity and working conditions may vary between species.

Phosphate buffered saline pH7. 4

B6 mouse FasL/BHK cells

Cytokine that binds to TNFRSF6/FAS a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects By similarity. Subunit structureHomotrimer Probable. Subcellular locationIsoform FasL: Cell membrane; Single-pass type II membrane protein. Isoform FasLS: Secreted. Tumor necrosis factor ligand superfamily member 6 soluble form: Secreted. Post-translational modificationThe soluble form derives from the membrane form by proteolytic processing By similarity. Involvement in diseaseNote=A deficiency in this protein is the cause of generalized lymphoproliferation disease phenotype (gld). Gld mice present lymphadenopathy and autoantibody production. The phenotype is recessively inherited. Sequence similaritiesBelongs to the tumor necrosis factor family.