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HAMSTER ANTI MOUSE CD178:FITC

HAMSTER ANTI MOUSE CD178:FITC

Manufacturer	GENWAY
Category	Antibodies Cell Biology Cell Status Apoptosis Primary Antibodies
Type	Antibody
Specific against	Mouse
Amount	0.1 mg
Host	Hamster
Item no.	20-783-314773
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-6E28F3
Specificity:	CD178
Isotype:	IgGSpecies Cross Reactivity: Reacts with: RatN. B. Antibody reactivity and working conditions may vary between species.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 0. 1mg/ml
Immunogen:	B6 mouse FasL/BHK cells
Specificity:	Recognises both mouse and rat CD178 otherwise known as Fas Ligand/ CD95L a 40kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily expressed by activated T cells and NK cells which can be induced on a variety of cells by radiation heat shock chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas) induces Fas-mediated apoptosis of target cells and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis. Clone MFL4 is reported to block CD178/CD95 induced apoptosis. AbD Recommended Negative Controls: HAMSTER (ARMENIAN) IgG NEGATIVE CONTROL:FITC
Function:	Cytokine that binds to TNFRSF6/FAS a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects By similarity. Subunit structureHomotrimer Probable. Subcellular locationIsoform FasL: Cell membrane; Single-pass type II membrane protein. Isoform FasLS: Secreted. Tumor necrosis factor ligand superfamily member 6 soluble form: Secreted. Post-translational modificationThe soluble form derives from the membrane form by proteolytic processing By similarity. Involvement in diseaseNote=A deficiency in this protein is the cause of generalized lymphoproliferation disease phenotype (gld). Gld mice present lymphadenopathy and autoantibody production. The phenotype is recessively inherited. Sequence similaritiesBelongs to the tumor necrosis factor family.

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Amount: 0.1 mg

available

Delivery expected until 5/30/2024