RAT ANTI MOUSE CD45:FITC

GWB-3A4257

IgG2b

Phosphate buffered saline

Mouse spleen cells.

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits and dephosphorylates SKAP1 and FYN By similarity. Catalytic activityProtein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subunit structureInteracts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes By similarity. Binds GANAB and PRKCSH. Ref. 12Subcellular locationMembrane; Single-pass type I membrane protein. Membrane raft By similarity.

The first PTPase domain interacts with SKAP1 By similarity. Post-translational modificationHeavily N- and O-glycosylated. Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. Sequence cautionThe sequence AAA39460. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39462. 1 differs from that shown. Reason: Erroneous initiation.