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POLE3 (polymerase (DNA directed). epsilon 3 (p17 subunit))

POLE3 (polymerase (DNA directed). epsilon 3 (p17 subunit))

ArtNr	18-003-42324
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-677D70
Similar products	18-003-42324
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Genway ID:	GWB-677D70
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human POLE3.
ELISA Titre:	1:312500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription. replication. and packaging.
Function:	Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA which is then incorporated into chromatin aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
Catalytic Activity:	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Subunit:	Consists of four subunits: POLE POLE2 POLE3 and POLE4. Interacts with CHRAC1. Together with CHRAC1 ACF1 and ISWI/SNF2H proteins it forms the ISWI chromatin-remodeling complex CHRAC.
Subcellular Location:	Nucleus (Potential).
Tissue Specificity:	Expressed in all tissues tested including heart brain placenta lung liver skeletal muscle kidney and pancreas. Summary: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription replication and packaging. [supplied by OMIM]. Bolognese. F. . et al. . (2000) Nucleic Acids Res. 28 (19). 3830-3838.

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Menge: 0.1 mg

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Lieferung vsl. bis 11.09.2025

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