RB1 (retinoblastoma 1 (including osteosarcoma))

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human RB1.

Transcription Factor Antibodies

Key regulator of entry into cell division that acts as a tumor suppressor. Directly involved in heterochromatin formation by maintaining overall chromatin structure and in particular that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1 SUV420H1 and SUV420H2 leading to epigenetic transcriptional repression. Controls histone H4 \' Lys-20\' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting chromatin-modifying enzymes to promoters. Inhibits the intrinsic kinase activity of TAF1. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding.

Nucleus.

Phosphorylated from S to M phase of the cell cycle and is dephosphorylated in G1. T but not E1A binds only to the unphosphorylated form.

Defects in RB1 are a cause of bladder cancer [MIM:109800].

Belongs to the retinoblastoma protein (RB) family. Summary: Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression (\' cure\' ) occurs in some cases. The retinoblastoma gene RB was the first tumor suppressor gene cloned and is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F (MIM 189971) and repress transcription of genes required for S phase (Hanahan and Weinberg 2000 [PubMed 10647931]). [supplied by OMIM]. Dasgupta. P. . et al. . (2004) Mol. Cell. Biol. 24 (21). 9527-9541.